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Feature selection, on the other hand, identifies the most relevant features using statistical tests (e.g., t-test for binary classification, Mann-Whitney U test as a non-parametric alternative, and ANOVA for multiclass classification), Minimum Redundancy - Maximum Relevance (mRMR) for selecting uncorrelated and informative features, and Linear Discriminant Analysis Effect Size (LEfSe) for incorporating biological relevance [299]
To date, the carnitine deficiency phenotype was observed in the context of (a) primary carnitine deficiency resulting from inactivating mutations in Octn2 gene, (b) secondary carnitine deficiency that may be caused by different metabolic abnormalities all ultimately leading to the loss of carnitine in the urine, and (c) patients with CKD undergoing hemodialysis and losing carnitine through the dialysis membrane (reviewed in ref
