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[DOI] [PMC free article] [PubMed] [Google Scholar] 25 .Castelli MC, Friedman K, Sherry J, et al

For patients who experience a paradoxical decrease in energy levels, it doesnt mean you should stop taking the B12 but instead decrease your dose by half (so take 2,500mcg every 7 days) or simply take 5,000mcg every 14 days instead

Calzada Ltd was aggressively pursuing this treatment route in the early 2010s, reporting in 2012 that AOD-9604 might promote cartilage creation and repair [in vitro] (Source)