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Choline breaks down fat as an energy source

Compared to controls, children with obesity presented higher concentrations in a variety of metabolites involved in energy homeostasis, branched-chain and aromatic amino acids, markers of oxidative stress, and nucleotide catabolites in both biological matrices, while other metabolic increments were exclusive for plasma (e.g., steroid hormones, bile acids) or erythrocytes (e.g., carnitine derivatives, methionine, N-acetylspermine, sphingolipids)

The animal evidence is consistent with the mechanistic findings

Lipoic acid can chelate (bind) with some pro-oxidant minerals to provide detoxification in the organism and neutralize these minerals