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Similarly, due to its ionic similarity to Zn 2 , Cd 2 can also enter roots via ZIP family transporters ( ZRT-, IRT-like Proteins ), such as ZIP1, ZIP4 , and ZIP8 , as well as NRAMPs (Natural Resistance-Associated Macrophage Proteins), which exhibit broad specificity for divalent metals (Tao and Lu 2022)

Upon direct binding with cytosolic DNA, cGAS is activated to catalyze the production of cyclic GMP-AMP (cGAMP), leading to the activation of the downstream sensor STING