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2, redness and swelling involving the entire forepaw

Similarly, ROS produced in normal physical processes play an important role in the maintenance of cell function, but excessive ROS may cause metabolic disorders, such as lipid peroxidation, and induce ferroptosis [74, 75]

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Its enzymatic function is based on two aspects: its catalytic activity and the auto- S -glutathionylation of GST by itself on Cys47 and Cys10, both of which disturb the subsequent interaction with c-Jun NH 2 -terminal kinase (JNK), resulting in the formation of a GST multimer 30 (Figure 3)