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[9] A 52-week double-blind RCT with 0.1% stabilized retinol showed 44% improvement in crow's feet wrinkles and 84% improvement in mottled pigmentation, with benefits still accumulating at the final time point

The catalase-triggered superoxide eruption reported here may provide a concise answer: the dietary fat, often emulsified by artificial emulsifiers or bile salts, would have created an enormous oil-water interface being exposed to ubiquitously distributed exogenous or endogenous catalase and resulted in superoxide eruption, which may, in turn, regulates phagocytosis and inflammation

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