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When filaggrin is low or not processed properly, the wall crumbles, water evaporates, irritants get in, and skin gets red, itchy, and inflamed

This battle is called oxidative stress

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To further assess potential T cell responses elicited by the charge pair mutations, a control heteroimmunoglobulin monoclonal antibody with the same engineered charge pair mutations as AMG 966 was tested alongside the standard version of the same control antibody