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For instance, several studies (124126) have shown that taurine reduces testicular tissue damage, DNA damage and apoptotic cells count by reducing hyperglycemia, oxidative stress (enhanced the antioxidant enzyme SOD, CAT, GPx activity) and inhibiting inflammation (reduced pro-inflammatory cytokine TNF- and IL-6), ER stress (reduced expression of calpain-1, caspase-12 and down-regulation of CHOP, GRP78 via eIF2 signaling)

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Feeding of a protein-deficient diet to rats has been shown to increase Hpid peroxidation (LPO) and to induce significant changes in the liver activities of catalase, glutathione peroxidase (GPX) and superoxide dismutase (SOD) in the liver 10,11