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10.1016/j.lfs.2020.118120 7 ChenY

SAdenosylhomocysteine inhibits NF Bmediated gene expression in hepatocytes and confers sensitivity to TNF cytotoxicity

Finally, the above approach to evaluate organoid-derived FVII function suggests that although these experiments are not specific for FVII activity per se, supernatants (supplemented with vitamin K) show hemostatic potential due to the secretion of serine proteases (probably gamma-carboxylated) into the conditioned medium that mimic the FVII effect

Research Challenges: Comparing clinical efficacy and trial data across different products becomes difficult without standardized terminology