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In obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and lowering NAD+ availability [2]

This helps doctors see if the treatment is working and if any changes are needed

PubMed 18068698 TB-4 / TB-500 product mislabeling documented bidirectional mislabeling between full-length TB-4 (43 aa) and the TB-500 fragment (residues 1723) in marketed peptide products: Esposito M et al