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10.1016/0012-1606(88)90070-X

demonstrated the beneficial effect of IL-22 in TLO assembly and autoimmunity (43)

Similar to free drug combinations, 2/1PHPPMs with a loaded drug mass ratio (PTX/HK) of 2:1 showed the highest cytotoxicity (lowest IC 50 value) and the best synergistic effect (lowest CI 50 value) (Figures 5F,G), suggesting that the optimal drug combinations dose for cocktail PPMs can be easily screened using free drugs

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