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J Stem Cell Res Transplant

Numerous studies in animal models submitted to infection and trauma (Reference Cruzat, Pantaleao and Donato7,Reference Cruzat, Bittencourt and Scomazzon9) , as well as critically ill and post-surgery (Reference Wang, Wu and Zheng29) patients, have demonstrated that exogenous administration of glutamine (both enteral and parenteral nutrition), significantly enhances the GSH system, increasing cellular resistance to lesions and reducing oxidative stress (Reference Cruzat, Macedo Rogero and Noel Keane4,Reference Smedberg and Wernerman30)

Furthermore, through the TRXTXNIP axis, Nrf2 activation indirectly inhibits NLRP3 activation by promoting the production of antioxidant enzymes that preserve TRX in a reduced state [90]

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