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miltiorrhiza (Danshen), significantly inhibits the EMT process in silica-induced pulmonary fibrosis models by suppressing the TGF-1/Smad signaling pathway ( In vitro studies demonstrated that Tan IIA treatment increased nuclear expression of Smad7, inhibited Smad2 and Smad3 phosphorylation by TR1, and reduced the nuclear accumulation of phosphorylated Smad3, thus impeding ECM biosynthesis and myofibroblast differentiation