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The main biochemical findings in the 69 patients were elevated serum lactate levels (mean 2.9 mmol/L) and elevated serum ammonia levels (mean 96 mol/L)

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139,140 In addition, recently, IDH1 and IDH2 gene mutations have been prevalent in several diverse malignancies, including glioma, AML, angioimmunoblastic lymphomas, chondrosarcoma, and melanomas

137 A multicenter study of activated charcoal for the treatment of IBS, including approximately 60% who reported constipation as a symptom, found it was well tolerated and efficacious in nearly 80% of individuals after 12 weeks of treatment