1 Introduction Osteoarthritis (OA) is among the most prevalent degenerative joint diseases globally, affecting more than 500 million people worldwide and ranking as the leading cause of disability among adults aged 50 years and older ( Ferroptosis, first reported in 2012, is a novel form of cell death distinct from classical apoptosis, pyroptosis, and necrosis ( Due to the possible critical role of ferroptosis in OA, there has been a surge of interest in elucidating its molecular mechanisms and exploring potential therapeutic strategies
demonstrated a positive correlation between serum butyric acid levels and PD-1 expression on circulating CD8+ and V2+ T lymphocytes in NSCLC patients ( Previous studies have demonstrated that SCFAs, especially butyrate, stimulate the generation of regulatory T cells (Treg cells) outside the thymus, contribute to the development of Treg cells in the colon, and are regulated by HDAC (143145)
Interestingly, male mice exhibited greater sensitivity to UV exposure, manifesting more severe inflammatory damages and an earlier onset of skin cancers [135]
Antioxidants for prostate cancer chemoprevention: Challenges and opportunities