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In patients who have had hysterectomies, estrogen-only formulations are more appropriate (as there is no need for progesterones uterus-protective effects)

Rare but serious complications, such as vascular occlusion, can occur if filler inadvertently enters a blood vessel

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It is also suitable for people who have had gastrointestinal surgeries (like gastric bypass) or have digestive disorders such as Crohns disease, which can impair nutrient absorption