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However, due to the unwanted side effects, such as glucose intolerance, insulin resistance, hypertension and edema, exerted by other functional domains of the intact hGH molecule limited its use as pharmacotherapy for obesity In other words, AOD9604 induces fat loss without the side effect of insulin resistance seen in many other peptides that stimulate growth hormone production/release

These include B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin)

This causes clumping and can trap undissolved peptides in a gel-like matrix

doi: 10.1080/13880209.2017.1299768