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Small molecules (rapamycin, metformin, quercetin), nutraceuticals (fisetin, salidroside), trace-element supplementation (zinc) and neuromodulatory procedures (HVPRF, VNS, photobiomodulation) all restore AMPK- or mTOR-regulated autophagy and shift microglia toward a reparative M2 phenotype

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As a double edge sword, iron chelation may prevent labile iron catalysing ferroptosis, but may also disrupt energy production

Moreover, cystatin C has recently emerged as a promising predictor of cardiovascular risk (Salgado 2013