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At the growth-factor level, BPC-157 modulates expression of EGF (epidermal growth factor), FGF (fibroblast growth factor), and TGF-beta in injured tissue, coordinating a multi-pathway repair response that few single-agent peptides can match

For chemotherapy, 5-FU (Roche) at a low dose of 10 mg kg 1 and a high dose of 60 mg kg 1 was intraperitoneally injected once a week alone or in combination with an anti-mouse VEGF neutralizing antibody plus imatinib

Although several theories with empirical support tackle the point, the causes of BIPN are multifactorial and not fully understood, it remains a potentially persistent adverse event that can lead to long-term objective neurological dysfunction (Li et al., 2020), thereby reducing the quality of life, weakening physical function, causing delays or dose reductions in chemotherapy, and in some cases even interrupting treatment, imposing a huge economic burden (Selvy et al., 2021)