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Most peptides do not have long term human safety data

HSC transplantation has been used for clinical treatment for a long time, and the ease of collection from peripheral blood or bone marrow, together with the non-invasive nature of administration, has made it a reliable treatment for ALS [116, 122]

In addition to long-lived proteins, AGEs can bind to proteins with short half-lives such as serum albumin, thereby activating RAGEs and inducing inflammatory responses followed by protein dysfunction and cell damage 34

Both of these CGA effects could potentially protect against NAFLD, although the direct effect of CGA on NAFLD has not been fully investigated or confirmed