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These metabolites may indirectly influence lipid peroxidation through their involvement in antioxidant defense or signal transduction pathways (Figure 13)

2014;111:E436775

Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 leads to potent monotherapy antitumor activity

As the HPT axis has long been involved in the research of depression (106), it is reasonable to believe that the dysfunction of the HPT axis in GD, with its effect of disrupting neurotransmitter metabolism, inducing oxidative stress, contributing to other complications and so forth, has a potentially vital effect on the development of depression