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Edited by: Kilberg MS, Haeusinger D

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Immortalized cellular models provide controlled environments for investigating the molecular and neurochemical pathways involved in neuronal function, while iPSCs and brain organoids, derived from patient-specific sources, offer significant advantage in translational research by facilitating direct comparisons of cellular phenotypes between patient-derived neurons and healthy-control neurons

In contrast to the well-documented changes in TGF1 expression, the regulatory mechanisms governing individual downstream signaling molecules under pathological conditions remain poorly understood 13