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The key node identification algorithms include betweenness centrality, degree centrality, closeness centrality, and eigenvector centrality, which help to locate the core regulatory genes or targets within networks (Zhao et al., 2022

Front Aging Neurosci (2022) 13:777962

Research on the impact of REEs has confirmed changes in gene activity related to protein processing in the endoplasmic reticulum, phosphate transport, and calcium and iron balance in cells [84,85]