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This discrepancy could be because the lower levels of MGMT methylation found in most HCC samples outweigh the relatively small proportion of increase in MGMT hypermethylation occurring in alcohol-associated HCC [108]

[1] Copper is an essential trace mineral involved in numerous biological processes, including collagen synthesis, wound healing, and antioxidant defence

The lethal concentration at 50% (LC 50 ), which is the lowest concentration of the extracts that inhibits 50% of the cells, was calculated using the trendline coefficient with the goodness of fit (R 2 ) 0