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Neuropsychopharmacology 46(8):14321441 Savitz JB, Drevets WC (2013) Neuroreceptor imaging in depression

We were exploring ways of developing peptides that bind selectively, and we were very successful at that, but then we confronted the problem that our short, 23-residue peptides are not promising therapeutic candidates primarily because they cannot get into cells, Keating says