acetaminophen overdose mechanism glutathione napqi Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update How a common drug causes

30 Three phases of colchicine poisoning include: 30 Gastrointestinal phase (10 24 hours) including abdominal pain, nausea/vomiting and diarrhoea Multiorgan phase (2 7 days) can include a wide range of serious adverse effects including paralytic ileus, myopathy, myocardial toxicity and severe cardiovascular dysfunction, respiratory failure and blood dyscrasias Recovery phase in those who survive (within a few weeks) Colchicine is contraindicated in patients with severe renal or hepatic impairment, significant gastrointestinal or cardiac conditions or pre-existing blood dyscrasias

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: mineralocorticoid receptor null mice: informing cell-type-specific roles

Zhan Y, Sun D, Gao J, Gao Q, Lv Y, Du T, et al