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[23] Patients develop a wide range of symptoms depending on the severity of the mutations

Extracellular vesicles EVs represent a diverse population of small, non-replicating, membrane-encapsulated particles released by nearly all cell types.113 114 Based on their biogenesis and size, EVs are categorised into three main groups: exosomes (50150 nm), microvesicles (1001000 nm) and apoptotic bodies (5002000 nm).113 114 These nanosized particles carry a distinct molecular signature composed of proteins, RNA (including miRNAs and long non-coding RNAs), lipids and even DNA fragments, which reflect the cell type of origin and the specific homeostatic or pathological stimuli that trigger their release.115 EVs are emerging as sophisticated mediators of intercellular communication

Metabolism of the one-ring open metabolites of the cardioprotective drug dexrazoxane to its active metal-chelating form in the rat

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