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Funding This work was supported by research funding through an Australian Research Council (ARC) Discover Project grant (DP180100474)

One of the main causes of decreased insulin secretion capacity in diabetes is oxidative stress

Both GPX1 expression and activity were substantially lower in mice fed a selenium-deficient diet than those in mice fed a normal diet, leading to decreased trabecular number, reduced femoral trabecular volume/total bone volume ratio, and trabecular separation 66