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The use of cyclosporine A as monotherapy was reported in 137 patients and provided an ORR of 83.2% (95% CI, 72.3-94.1, I 2 , 58%), whereas 124 patients were reported to receive cyclosporine combined with corticosteroids, providing an ORR of 77.3% (95% CI, 69.9-84.7, I 2 , 0%)

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This orthostatic component suggests vasodilation may be significant enough in some individuals to temporarily reduce blood flow to the brain during position changes

Images summary Ehlers-Danlos Syndrome is a congenital connective tissue disorder most commonly caused by a variety of mutation in collagen forming genes