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doi: 10.3168/jds.2019-16631 72 LeeCLobosNEWeissWP

Al fijarse al dominio extracelular, provoca autofosforilacin de residuos de tirosina y reclutamiento de sustratos IRS-1/IRS-2, disparando dos rutas principales: la va PI3K/Akt, asociada a supervivencia celular, captacin de glucosa e inhibicin de la apoptosis, y la va MAPK/ERK, vinculada a proliferacin y crecimiento