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Additionally, the Papot group developed a prodrug by combining a galactoside trigger with a folate receptor (FR) ligand, resulting in the tubulin inhibitor monomethyl auristatin E (MMAE) release (Legigan et al., 2012)

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The method of reducing the single dose with the same total dose can make pharmacokinetics safer, lower trough concentration, and reduce the accumulation of cisplatin in the inner ear ( Pedmark, a sodium thiosulfate (STS) formulation, is the first and only novel drug approved by the US FDA to prevent the risk of cisplatin ototoxicity in children aged 1 month and older with localized non-metastatic solid tumors