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Abstract Systemic metabolic abnormalities including insulin resistance, lipid dysregulation, mitochondrial dysfunction and inflammation are highly prevalent in psychiatric illness and may contribute to increased mortality, illness severity and treatment resistance

Xue JP, Wang G, Zhao ZB et al (2014) Synergistic cytotoxic effect of genistein and doxorubicin on drug-resistant human breast cancer MCF-7/Adr cells

4C), with a possibility of distal ubiquitin chains also forming the K48 linkage

The recent discovery of cuproptosis has provided a novel target to overcome the cell death resistance of cancer cells, further exemplifying the potential of copper in cancer therapy