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The glucagon receptor component is the real differentiator

Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules

Eur J Pharmacol 218:339341 Xie J, Sun B, Du J et al (2011) Phosphatidylinositol 4,5-bisphosphate [PIP(2)] controls magnesium gatekeeper TRPM6 activity

The only large study of healthy adults examining B12 supplement safety, using NHANES data, found no association between B12 supplementation and increased mortality at any dose, including 1,000 g/day or more (Wolffenbuttel, 2020)