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It is established that glutathione peroxidase-4 (GPX4) deficiency or inhibition enhances the production of endogenous HNE in vivo and in vitro (56-58)

If the size of the lesion is between 1 and 3 cm, then it receives a score of A2

[DOI] [PMC free article] [PubMed] [Google Scholar] 1127.van den Oever I.A.M., Baniaamam M., Simsek S., Raterman H.G., van Denderen J.C., van Eijk I.C., Peters M.J.L., van der Horst-Bruinsma I.E., Smulders Y.M., Nurmohamed M.T