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For many years, Lippard has studied the mechanism of cisplatins action and has pursued similar drugs that could be more powerful, work against more types of cancer, have fewer side effects and evade cancer-cell resistance

It is important to realize that patients with baseline functional anemia (e.g., sickle cell anemia or carboxyhemoglobinemia) will become symptomatic at lower methemoglobin fractions [1]

In terms of anti-inflammatory effects, folic acid suppresses the activation of the NF-B pathway induced by ROS and Hcy, thereby downregulating the expression and secretion of pro-inflammatory cytokines such as TNF- , IL-6, and IL-1 (67)

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