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The Spalt transcription factors regulate cell proliferation, survival and epithelial integrity downstream of the Decapentaplegic signalling pathway

These findings suggest that while FOXO4 is involved in the senescence pathway, it also plays a role in maintaining the viability of senescent Leydig cells by suppressing their apoptotic response, which could contribute to the accumulation of senescent cells [1]

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2b), we interrogated SPIED, finding a large number (393) of positively associated compounds, with 156 in common with those obtained using our broad oligodendroglial signature (Fig