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A 2015 review published in BioMed Research International by Pickart, Vasquez-Soltero, and Margolina provided a comprehensive overview of GHK-Cu as a natural modulator of multiple cellular pathways in skin regeneration

However, further studies are required to clarify the roles of individual mediators across distinct immune cell subsets, as specific PRLMs may activate different pro-resolution pathways and induce heterogeneous immune responses during inflammation

This shift is largely mediated by suppression of the NF-B signaling pathway