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The PK parameters assessed were the area under the curve (AUC) and peak plasma concentration (C max ), which were quantitatively assessed based on a predefined criterion of two-fold range (0.52.0) of the predicted/observed ratio

Consideration of variability of these data allows for extrapolation of a range of in vivo equivalent doses across individuals rather than a single value, which more accurately reflects the distribution of population responses that occur from exposure to a chemical (Wetmore et al

The positively charged amino acids in Apo B could bind to PGs via negatively charged GAGs 37,60

Identification of histone methyltransferase NSD2 as an important oncogenic gene in colorectal cancer