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Its key feature lies in the competitive utilization of the same substrate by iNOS (also known as Nos2) and Arg1: the former generates NO and is closely associated with pro-inflammatory effects, whereas the latter produces ornithine and polyamines and participates in tissue repair and immune regulation ( Under classical pro-inflammatory stimulation (such as LPS/IFN-), iNOS expression is upregulated and catalyzes the conversion of Arg into NO and citrulline

Ruvolo P, Qiu Y, Ruvolo V, Wang RY, Zeng Z, Burks J, Pan R, Hail Jr N, McQueen T, Yoo SY, Kornblau SM, and Andreeff M

Update on transcobalamin deficiency: Clinical presentation, treatment and outcome

Nat Rev Cardiol 15:457470