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Pharmacology 17(3):157162 Beaudet AL, Scriver CR, Sly WS, Valle D (1995) Genetics, biochemistry, and molecular basis of variant human phenotypes

There were only two metabolites, asparagine and N -acetylgluatmate, detected at a lower concentration in the gdh3 / gdh3 cells grown on arginine medium than on proline medium

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NAMPT, as intracellular and extracellular factor, exerts a direct role on tumor cells increasing tumor aggressiveness, correlating with worse prognosis and regulating different processes including metabolic adaptation, DNA repair, gene expression, signaling pathways, cell growth, invasion, stemness, epithelial to mesenchymal transition program, metastatization, angiogenesis, secretion of both pro-inflammatory and immunosuppressive cytokines, resistance to genotoxic stress, as reviewed in Dalamaga et al