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Degradation of hexokinase 2 blocks glycolysis and induces GSDME-dependent pyroptosis to amplify immunogenic cell death for breast cancer therapy

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Abstract Ferroptosis is a novel type of programmed cell death that was discovered in recent years and is closely associated with disorders in iron cycling, abnormal lipid metabolism, excessive intracellular reactive oxygen species, and cellular antioxidant-related signaling pathways

However, this leads to complete loss of the CAR-T cells ( Applied to SSTR-targeted therapy for pancreatic NENs, a promising regulated approach has been proposed