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Biochim Biophys Acta Rev Cancer 1766:122 Lang CH, Nystrom GJ, Frost RA (1999) Regulation of IGF binding protein-1 in hep G2 cells by cytokines and reactive oxygen species

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Similarly, the quinolinium containing parent analogue 1-MQ also lacked passive diffusion properties (Table 1), suggesting that the lipophilicity and drug-like permeability properties of analogues within the methylquinolinium series had to be improved via chemical modification