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In vitro studies showed that pretreatment of human neuroblastoma cells (SH-SY5Y) with melatonin-inhibited oxaliplatin-induced proteolytic activation of caspase-3, inactivation of poly (ADP-ribose) polymerase and DNA damage, thereby rendering resistant apoptotic cells dead, suggesting that melatonin plays a significant role in reducing oxaliplatin-induced neurotoxicity [47]