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During toxic exposure, CMA becomes activated, selectively degrading proteins altered by toxic compounds (89)

After a 1 g IV dose, average concentrations of ceftriaxone, determined from 1 to 3 hours after dosing, were 581 mcg/mL in the gallbladder bile, 788 mcg/mL in the common duct bile, 898 mcg/mL in the cystic duct bile, 78.2 mcg/g in the gallbladder wall and 62.1 mcg/mL in the concurrent plasma

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76 This finding is of interest because for many common cancers, adding molecularly targeted agents to radiotherapy can increase preclinical cure rates, 79,80,81 and currently the only targeted agent clinically approved for this application is the EGFR antagonist, cetuximab