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In contrast, the inhibition of c-Myc in tamoxifen (TAM) resistant cells decreases cell viability and glucose uptake, and prevents proper regulation of the glutaminase-glutamine synthetase (GLS/GAC-GLUL) system (Miller et al., 2011

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At high levels of oxidative stress, or at the point of no return, Nrf2 is destroyed, and thereby, the Nrf2-dependent pro-survival response is inhibited, and the pro-apoptotic response initiates apoptosis