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A significant body of work, often based on neuroimaging techniques such as positron emission tomography (PET) and blood-oxygen-level-dependent functional magnetic resonance imaging (BOLD-fMRI), has reported a disproportionate increase in glucose utilization relative to oxygen consumption during brain activation

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Homoserine converts to O -succinyl homoserine, which then reacts with cysteine to produce cystathionine, which is cleaved to yield homocysteine

Brain regions that were hypermetabolic during acute COVID turn out to become hypometabolic in long COVID (179)