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PMM is a critical regulator of the MCPs metabolic pathway

Increased LL37 in psoriasis and other inflammatory disorders promotes LDL uptake and atherosclerosis

While Phase II trials in heart failure and primary mitochondrial myopathy did not meet primary efficacy endpoints, the TAZPOWER trial in Barth syndrome demonstrated significant improvements in muscle strength and sixminute walk distance, leading to FDA accelerated approval in 2025 [3] [10]