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[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Hansen KD

coordinated benchmarking will be critical to avoid a fragmented evidence base

2.3 Genetic determinants of tumor heterogeneity 2.3.1 Somatic mutations and clonal architecture Genetic heterogeneity originates from the elevated mutational burden characteristic of malignant cells, driven by defects in genome maintenance pathways, replication stress, oncogene-induced DNA damage, and exposure to endogenous and exogenous mutagens