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Description

Most research on the peptide has been done in animals although some human studies have been carried out [2]

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More in detail, microenvironmental factors (e.g., food, microbiota, bile acids) would permeate in excess through a leaky IEB, allowing amplification of signaling from the lumen to deeper mucosal and muscle layers, including overstimulation of the mucosal immune system (197)

Upon binding to biologically active HGF, c-Met undergoes dimerization and recruits downstream signaling effector molecules, including PI3K, PLC-?1, and STAT3