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Alcohol-induced epigenetic modifications of genes involved in glutamatergic and GABAergic signaling have a variety of effects, such as altered synaptic plasticity and withdrawal excitotoxicity, which increase an individuals risk of developing AUD

By employing a lentivirus-based system to provide GPx1 to neuroblastoma cells in vitro, Ridet et al

A follow-up consultation and evolutionary analysis monitoring are then scheduled, typically at 3 months, focusing mainly on the parameters that were previously found to be altered

This holistic perspective is critical for the development of multi-targeted therapeutic strategies, as single-pathway interventions are unlikely to address the multifactorial nature of the disease